AI applications in healthcare across the GCC — including medical imaging, clinical decision support, genomics, and health informatics from Gulf universities and hospitals.
KAUST and AlFaisal University have signed an MOU to establish a joint M.D.-Ph.D. program, the first of its kind in Saudi Arabia. AlFaisal medical students selected for the program will enroll in a KAUST Ph.D. program focused on basic research, smart-health tools, and precision medicine. Graduates will become clinician-scientists implementing smart-health methods in the Saudi healthcare system. Why it matters: This program will cultivate a new generation of leaders in smart health and precision medicine, fostering evidence-based practices in Saudi healthcare.
This paper introduces a method for automatically designing convolutional neural network (CNN) architectures tailored for diabetic retinopathy (DR) diagnosis using fundus images. The approach uses k-medoid clustering, PCA, and inter/intra-class variations to optimize CNN depth and width. Validated on datasets including a local Saudi dataset and Kaggle benchmarks, the custom-designed models outperform pre-trained CNNs with fewer parameters.
KAUST researchers have developed a passive cooling system that uses solar energy to evaporate water and regenerate salt for reuse, achieving temperatures as low as 3.6 degrees Celsius. The system uses ammonium nitrate (NH4NO3) due to its high solubility and low cost. The crystallized salt stores solar energy and can be reused for cooling when needed. Why it matters: This off-grid design offers a sustainable and inexpensive cooling solution for communities in hot regions with limited electricity access, addressing a critical need exacerbated by climate change.
Researchers at KAUST and Peking University Third Hospital have created a novel blastoid model for studying early human development using extended pluripotent stem cells (EPSCs). The blastoid is a 3D cell model mimicking the blastocyst phase, avoiding ethical concerns associated with using human embryos. The team showed that blastoids can be cultured to mimic post-implantation development, offering insights into early cell lineages. Why it matters: This innovation provides a way to study human embryogenesis without the ethical constraints of using actual embryos, potentially advancing our understanding of miscarriage and birth defects.
KAUST researchers demonstrated that Beneficial Microorganisms for Corals (BMC) can help corals recover from thermal stress by stimulating immune processes and rebuilding their microbiome. The study, published in Science Advances, showed that probiotic treatments can protect bleached corals from death. The research was conducted at the Federal University of Rio de Janeiro (UFRJ) and the KAUST Red Sea Research Center, with funding from the Great Barrier Reef Foundation and the Tiffany & Co Foundation. Why it matters: This finding offers a promising solution for mitigating the impacts of climate change on coral reefs, which are vital ecosystems facing increasing threats from warming ocean temperatures.
A KAUST-led team developed NIRVANA, a portable, briefcase-sized device for rapid detection and sequencing of SARS-CoV-2, influenza, and other viruses. The test utilizes isothermal recombinase amplification (RPA) and was validated on clinical samples and wastewater. NIRVANA can differentiate SARS-CoV-2 strains and doesn't require expensive infrastructure. Why it matters: This innovation enables rapid, decentralized virus detection and surveillance, crucial for pandemic response and monitoring new variants across the region.
A KAUST-led study published in Science found overwhelming evidence that man-made noise negatively impacts marine fauna and their ecosystems, disrupting behavior, physiology, and reproduction. The researchers assessed over 10,000 papers to demonstrate that noise pollution from shipping, fishing, and infrastructure development harms marine life from invertebrates to whales. They call for human-induced noise to be considered a prevalent stressor at the global scale and for policy to be developed to mitigate its effects. Why it matters: This research highlights the need to consider acoustic dimensions in ocean health restoration efforts, promoting management actions to reduce noise levels and allow marine animals to re-establish their use of ocean sound.
Khaled Alsayegh at the King Abdullah International Medical Research Center is creating a Saudi Stem Cell Donor Registry, with 80,000 potential donors identified. The aim is to identify universal donors, reprogram their cells into induced pluripotent stem (iPS) cells, and create a gene bank for matched tissue transplants. Alsayegh is collaborating with Jesper Tegnér at KAUST to create pacemaker cells using single-cell RNA sequencing. Why it matters: This initiative could revolutionize precision medicine in KSA by providing readily available, matched cells for transplants, reducing the need for patient-specific reprogramming and improving treatment outcomes.
KAUST and Janssen Pharmaceutical (Johnson & Johnson) are collaborating to research and innovate in neglected tropical diseases, focusing on dengue fever. They signed an MoU to establish a dengue fever research program and an infectious disease R&D center at KAUST's National BioPark. The partnership marks Johnson & Johnson's first university collaboration in Saudi Arabia. Why it matters: This collaboration signifies a major step in localizing disease research within Saudi Arabia and leveraging KAUST's AI, genomics, and data simulation expertise to address global health challenges.
A retrospective study in Abu Dhabi, UAE, developed a machine learning-based prognostic system to predict the risk of seven complications in COVID-19 patients using data from 3,352 patient encounters. The system, trained on data from the first 24 hours of admission, achieved high accuracy (AUROC > 0.80) in predicting complications like AKI, ARDS, and elevated biomarkers in geographically split test sets. The models primarily used gradient boosting and logistic regression.
The study compares deep learning models trained via transfer learning from ImageNet (TII-models) against those trained solely on medical images (LMI-models) for disease segmentation. Results show that combining outputs from both model types can improve segmentation performance by up to 10% in certain scenarios. A repository of models, code, and over 10,000 medical images is available on GitHub to facilitate further research.
A KAUST team led by Xin Gao developed an AI model for COVID-19 detection from CT scans, addressing limitations of existing methods. The model incorporates a novel embedding strategy, a CT scan simulator, and a 2.5D deep-learning algorithm. Tested at King Faisal Specialist Hospital, the model demonstrated high accuracy in detecting COVID-19 cases. Why it matters: This research provides a valuable tool for rapid and accurate COVID-19 diagnosis in the region, especially in early-stage infections, improving healthcare outcomes.
The paper proposes a method for causal inference using satellite image time series to determine the impact of interventions on climate change, focusing on quantifying deforestation due to human causes. The method uses computer vision and deep learning to detect forest tree coverage levels over time and Bayesian structural causal models to estimate counterfactuals. The framework is applied to analyze deforestation levels before and after the hyperinflation event in Brazil in the Amazon rainforest region.
KAUST researchers are undertaking a project to improve global date palm production and protection by studying the date palm genome, collecting samples from ancient palms near Madinah. They aim to develop new breeding strategies for faster, healthier, and more pest-resistant palms. The research involves advanced genome sequencing and the creation of molecular tools to improve date palm agriculture, including rapid sex determination methods and gene editing. Why it matters: This research is critical for enhancing date production in arid regions like Saudi Arabia, which is a major global producer, and for ensuring food security amidst climate challenges.
The Saudi Vaccine and Biomanufacturing Center (SVBC), the first of its kind in the Middle East, broke ground at KAUST on December 15. The center will develop vaccines and biopharmaceutical products under good manufacturing practice (GMP) standards. It is a joint project championed by the Ministry of Energy, Industry and Mineral Resources through the Industrial Clusters Program and supported by KACST. Why it matters: The center will serve as a national platform for pharmaceutical innovation and address epidemic risks in the Kingdom, such as MERS-CoV.
The Research Products Development Company (RPDC) signed an agreement with The Saudi Vaccine and Biomanufacturing Center (SVBC) to establish a research and industrial center in Saudi Arabia for vaccine and biopharmaceutical development. Supported by KACST and hosted by KAUST, the SVBC will provide a state-of-the-art facility and a training platform. Cooperation agreements were also signed with GE for equipment supply and with Fujifilm Dayosent Biotechnology for MERS-CoV treatment development. Why it matters: This initiative aims to localize vaccine and advanced treatment industries in Saudi Arabia, create technical jobs, and reduce reliance on imports in line with Vision 2030.
KAUST's Professor Carlos Duarte contributed to sequencing the genome of Zostera marina (eelgrass), work published in Nature. The research identifies gene loss and adaptation mechanisms related to the plant's transition from land to marine environments. Eelgrass developed salt resistance, which could inform selective breeding for salt-tolerant food crops. Why it matters: Understanding the eelgrass genome can help in conservation efforts and provide insights into plant adaptation to climate change and marine environments.
KAUST researchers led by Dr. Muhammad Hussain have developed a flexible, transparent silicon-on-polymer based FinFET inspired by the folded architecture of the human brain's cortex. The team created a 3D FinFET on a flexible platform without compromising integration density or performance. They aim to demonstrate a fully flexible silicon-based computer by the end of the year. Why it matters: This research could lead to the development of ultra-mobile, foldable computers and integrated circuits, advancing the field of flexible electronics in the region.
KAUST researchers led by Dr. Niveen Khashab have developed thermosensitive liposomes for controlled drug release, particularly in cancer therapies. The liposomes are designed to release drugs only when they reach heated tumor tissue, minimizing systemic side effects. Cholesterol moieties are used as anchors to create a "nail" or "comb" effect, enabling temperature-triggered drug release inside cells. Why it matters: This targeted drug delivery system could significantly improve the efficacy and reduce the toxicity of cancer treatments.
KAUST researchers developed a new single-molecule imaging method called the cumulative-area (CA) method. This method allows for simultaneous characterization of size, shape, and conformational dynamics of individual molecules, along with accurate determination of diffusion kinetics. The researchers demonstrated the CA method's effectiveness on nano- and micro-sized objects, extracting quantitative information about size, diffusion, and relaxation time. Why it matters: This advancement expands the capabilities of molecule imaging techniques in the region and has potential applications in polymer dynamics research and the study of molecular mechanisms within cells.
An MBZUAI team led by Thamar Solorio and Monojit Choudhury received a Google Academic Research Award to study how AI can better understand and respond to human loneliness in digital spaces. The project will examine how loneliness is expressed online, how conversational agents can detect it, and what healthier AI companionship could look like in collaboration with Georgia Tech. The team aims to define digital loneliness and its expression in online conversations with AI. Why it matters: This research addresses a growing global issue by exploring the ethical and psychological implications of AI companionship, potentially leading to safer and more beneficial AI interactions.
MBZUAI researchers have developed a new method called "Byzantine antidote" (Bant) to defend federated learning systems against Byzantine attacks, where malicious nodes intentionally disrupt the training process. Bant uses trust scores and a trial function to dynamically filter out corrupted updates, even when most nodes are compromised. The system can identify poorly labeled data while still training models effectively, addressing both unconscious mistakes and deliberate sabotage. Why it matters: This research enhances the reliability and security of federated learning in sensitive sectors like healthcare and finance, enabling safer collaborative AI development.
MBZUAI researchers are refining AI techniques to improve cancer diagnosis for colorectal and breast cancer, both common in the Middle East. They are using "few-shot tissue image generation," in which AI generates data for training AI models to recognize lesions, addressing the challenge of limited training data. The developed framework improves the efficiency of radiologists in breast cancer diagnosis, leading to better detection of breast lesions and timely treatment interventions. Why it matters: These advancements in AI-aided diagnostics can lead to earlier and more accurate cancer detection, ultimately improving patient outcomes in the region and beyond.
MBZUAI's BiMediX2, a bilingual healthcare multi-modal model, won Meta's Llama Impact Innovation Award for its potential in solving healthcare accessibility challenges across the Middle East and Africa. Built using Llama 3.1, the model understands medical queries in both English and Arabic, interprets medical images, and is integrated as a chatbot on Telegram with speech functionality. The model was also presented at the AI for Sustainable Development Platform Launch Event and integrated into the UNDP for telemedicine. Why it matters: The model's bilingual capabilities and accessibility on low-cost devices and speech-based interaction have potential to improve healthcare access for marginalized populations in the region.
MBZUAI researchers developed MedAgentSim, a simulated hospital environment to evaluate AI diagnostic abilities. The simulation uses LLM-powered agents to mimic doctor-patient conversations, providing a dynamic assessment of diagnostic skills. The system includes doctor, patient, and evaluator agents that interact within the simulated hospital, making real-time decisions. Why it matters: This research offers a more realistic evaluation of AI in clinical settings, addressing limitations of current benchmarks and potentially improving AI's use in healthcare.
MBZUAI researchers co-led a study published in Nature demonstrating that GluFormer, an AI foundation model trained on continuous glucose monitoring (CGM) data, more accurately predicts long-term diabetes and cardiovascular risk than current clinical standards. GluFormer, built on a transformer architecture and trained using NVIDIA AI infrastructure on over 10 million CGM measurements, forecasts individual health risks using short-term glucose dynamics. In a 12-year follow-up, the model captured 66% of new-onset diabetes cases and 69% of cardiovascular-death events in its highest-risk group, outperforming established CGM-derived metrics across 19 external cohorts. Why it matters: The development of GluFormer represents a significant advancement in personalized healthcare, enabling proactive and individualized health strategies through the analysis of dynamic glucose data.
MBZUAI has launched master’s and Ph.D. programs in computational biology, expanding its research into life sciences. This includes projects like AIDO (AI-Driven Digital Organism) and analysis of the Emirati Genome Program. The programs are part of MBZUAI’s School of Digital Public Health and aim to integrate computational biology with precision medicine. Why it matters: This initiative supports the UAE's vision for a knowledge-based economy and its ambition to become a global center for scientific and technological progress in biotechnology and healthcare.
MBZUAI researchers have developed MorphDiff, a diffusion model that predicts cell morphology from gene expression data. MorphDiff uses the transcriptome to generate realistic post-perturbation images, either from scratch or by transforming a control image. The model combines a Morphology Variational Autoencoder (MVAE) with a Latent Diffusion Model, enabling both gene-to-image generation and image-to-image transformation. Why it matters: This could significantly accelerate drug discovery and biological research by allowing scientists to preview cellular changes before conducting experiments.
MBZUAI and GenBio AI have won the UAE AI Award 2025 in the AI Scientific Research category for their "Unified Protein Language Modeling Framework". The winning project enables AI to learn protein function, generate sequences, and predict 3D structures. The AI-driven simulation approach aims to accelerate drug development, reduce costs, and improve success rates. Why it matters: This award highlights the UAE's commitment to fostering AI innovation in biomedicine and drug discovery, positioning the region as a leader in AI-driven healthcare advancements.
MBZUAI researchers developed ClinGRAD, a multimodal graph neural network that analyzes genomic data, MRI scans, and clinical information to classify dementia types (Alzheimer's, vascular, etc.). The system addresses the challenge of high misdiagnosis rates (up to 30%) in dementia, where incorrect diagnoses can significantly impact patient life expectancy. ClinGRAD aims to be an interpretable AI system, providing explainability to clinicians. Why it matters: Accurate and early diagnosis of dementia subtypes is crucial for slowing disease progression and improving patient care in the region, where the prevalence of dementia is expected to rise significantly.
MBZUAI researchers presented DEFUSE-MS at MICCAI 2025, a novel AI system for analyzing changes in MRI scans of multiple sclerosis (MS) patients. DEFUSE-MS uses a deformation field-guided spatiotemporal graph-based framework to identify new lesions by reasoning about how the brain has changed. The model constructs graphs of small regions within baseline and follow-up MRIs, linking them across time with edges enriched with learned embeddings of the deformation field. Why it matters: DEFUSE-MS reframes the task from simple "spot the difference" to understanding structural changes, potentially improving the speed and accuracy of MS diagnosis and treatment monitoring.
MBZUAI and the Department of Health – Abu Dhabi (DoH) have signed an agreement to collaborate on AI research across genomics, precision medicine, robotics, and AI-powered diagnostics. Signed on October 13, 2025, the MoU aims to drive breakthroughs in disease prevention, early detection, and therapeutics. The partnership seeks to translate AI research into tangible improvements in patient care within Abu Dhabi and beyond. Why it matters: This partnership signifies a major push to establish Abu Dhabi as a leader in biomedical research and AI-driven healthcare innovation.
MBZUAI and Cleveland Clinic Abu Dhabi jointly showcased AI applications to address UAE healthcare challenges, focusing on diabetes, heart disease, and vision loss. The event highlighted AI-powered robots for surgical tool guidance, autonomous ultrasound systems, and AI-based eye diagnostics for early disease detection. Researchers presented advances in AI-powered intrabody navigation, robotic ultrasound imaging, and AI-based oculomics. Why it matters: These AI innovations have the potential to transform healthcare delivery in the UAE, improving surgical outcomes, democratizing access to diagnostic imaging, and enabling earlier disease detection.
MBZUAI and MIT Schwarzman College of Computing have launched a collaborative research program to advance AI across scientific discovery, human thriving, and planetary health. The program will involve faculty, students, and research staff from both institutions, with projects jointly led by principal investigators from each. The collaboration aims to strengthen AI foundations and accelerate its application to pressing societal challenges, aligning with both MIT's goals and the UAE's mission to become a global AI innovation hub. Why it matters: This partnership between a leading UAE AI university and a top US institution will foster impactful AI research and development, contributing to both regional and global advancements in the field.
MBZUAI researchers Darya Taratynova and Shahad Hardan developed Forget-MI, a method for making clinical AI models "unlearn" specific patient data without retraining the entire model. Forget-MI addresses the challenge of removing patient data from AI models trained on multimodal records (like chest X-rays and reports) due to regulations like GDPR and HIPAA. The method unlearns both unimodal (image or text) and joint (image-text) associations while retaining overall accuracy using a late-fusion multimodal classifier. Why it matters: This research provides a practical solution to a critical privacy concern in healthcare AI, enabling compliance with data protection regulations and fostering trust in AI-driven medical applications.
MBZUAI researchers are introducing MedNNS, a system to be presented at MICCAI 2025, that recommends the best AI architecture and initialization for medical imaging tasks. MedNNS addresses the challenge of inefficient trial-and-error in building medical imaging AI by reframing model selection as a retrieval problem. The system employs a Once-For-All ResNet-like model and a learned meta-space of 720k model-dataset pairs, using dataset embeddings to predict optimal model performance. Why it matters: By automating model selection, MedNNS promises to significantly reduce the time and resources required to develop effective AI solutions for healthcare, particularly in medical imaging.
MBZUAI and Quris-AI have partnered to launch a Bio-AI center in Abu Dhabi during Abu Dhabi Sustainability Week. The center will focus on developing personalized medications tailored to the MENA region's diverse populations, leveraging Quris-AI's 'patient-on-a-chip' technology and MBZUAI's AI expertise. Quris-AI is establishing a UAE subsidiary, Quris-UAE, in Abu Dhabi as part of this collaboration. Why it matters: This initiative positions Abu Dhabi as a hub for Bio-AI research and personalized medicine, potentially accelerating drug development and reducing clinical trial failures in the region.
MBZUAI researchers developed a new approach called Multimodal Optimal Transport via Grounded Retrieval (MOTOR) to improve the accuracy of vision-language models for medical image analysis. MOTOR combines retrieval-augmented generation (RAG) with an optimal transport algorithm to retrieve and rank relevant image and textual data. Testing on two medical datasets showed that MOTOR improved average performance by 6.45%. Why it matters: This technique addresses the challenges of limited specialized medical datasets and computational costs associated with training AI models for medical image interpretation, offering a more efficient and accurate solution.
MBZUAI researchers developed AirCast, a novel AI model for improved air pollution forecasting, which won the best paper award at the TerraBytes workshop during ICML. AirCast fuses weather and chemistry data using a Vision Transformer and frequency-weighted MAE to better predict extreme events like Saharan dust storms. In tests across the Middle East and North Africa, AirCast reduced PM2.5 error by 33% compared to a persistence baseline and outperformed the CAMS physics model. Why it matters: Accurate air pollution forecasting is critical for public health in the GCC region, and this research demonstrates a significant advancement using AI to address this challenge.
MBZUAI researchers have developed a new kernel-based method to identify dependence patterns in data, especially in small regions exhibiting 'rare dependence' where relationships between variables differ. The method uses sample importance reweighting, assigning more importance to regions with rare dependence. Tested on synthetic and real-world data, the algorithm successfully identified relations between variables even with rare dependence, outperforming traditional methods like HSIC. Why it matters: This advancement can improve data analysis in fields like public health, economics, genomics, and AI, enabling more accurate insights from complex observational data.
MBZUAI Ph.D. student Raza Imam and colleagues presented a new benchmark called MediMeta-C to test the robustness of medical vision-language models (MVLMs) under real-world image corruptions. They found that top-performing MVLMs on clean data often fail under mild corruption, with fundoscopy models particularly vulnerable. To address this, they developed RobustMedCLIP (RMC), a lightweight defense using few-shot LoRA tuning to improve model robustness. Why it matters: This research highlights the critical need for robustness testing in medical AI to ensure reliability in clinical settings, particularly in resource-constrained environments where image quality may be compromised.
The Human Phenotype Project (HPP), led by researchers from Mohamed bin Zayed University of Artificial Intelligence (MBZUAI), published findings in Nature Medicine detailing an understanding of the health-disease continuum. The HPP involves deep and longitudinal profiling of approximately 28,000 participants, collecting diverse data including medical history, lifestyle, blood tests, and molecular profiling. The project aims to create AI-based predictive models for disease onset and progression, and digital twins to simulate interventions. Why it matters: This research can transform precision medicine and preventative care in the UAE by creating personalized digital twins that can simulate interventions and predict health trajectories.
MBZUAI and Corniche Hospital researchers have developed FetalCLIP, a foundation model for analyzing fetal ultrasound images to detect congenital conditions. FetalCLIP outperformed other foundation models on ultrasound analysis tasks. The AI model aims to improve the early diagnosis of ailments like congenital heart defects. Why it matters: This innovation has the potential to dramatically improve health outcomes for millions of children annually by providing physicians with better insights into fetal health.
MBZUAI researchers developed FetalCLIP, an AI model trained on 210,000 ultrasound images for fast and reliable interpretation of fetal scans. MBZUAI's President Eric Xing contributed to the General Expression Transformer (GET), an AI foundation model acting as a biological simulator to predict gene behavior. MBZUAI and Carleton University created MedPromptX for quicker disease diagnosis and treatment plans using multimodal AI. Why it matters: These AI advancements from MBZUAI have the potential to revolutionize healthcare in the region and globally, from prenatal care to drug discovery and personalized medicine.
MBZUAI doctoral student Mai A. Shaaban and colleagues developed MedPromptX, a system that analyzes chest X-rays and patient data to aid lung disease diagnoses. MedPromptX uses multimodal large language models with visual grounding and few-shot prompting, trained on a new dataset of 6,000 patient records (MedPromptX-VQA) derived from MIMIC-IV and MIMIC-CXR. The system addresses the challenge of incomplete electronic health records by leveraging the knowledge embedded in large language models to interpret lab results. Why it matters: This research advances AI-driven medical diagnostics by integrating diverse data sources and addressing data gaps, potentially leading to quicker and more accurate diagnoses.
MBZUAI researchers developed a new deep learning method for rapid and accurate estimation of clinical measurements from echocardiograms. The method focuses on improving the measurement of the left ventricle ejection fraction, a key indicator of heart health. Their deep learning approach improves upon previous methods by better organizing data representation, enhancing performance and transferability. Why it matters: The AI-driven solution can potentially reduce analysis time for cardiologists, improve patient care, and be particularly beneficial in regions with limited healthcare resources.
MBZUAI researchers developed a method to adapt Meta's Segment Anything Model (SAM) for medical image segmentation, addressing its performance gap with natural images. Their approach improves SAM's accuracy without requiring extensive retraining or large medical image datasets. The research, led by Chao Qin, was nominated for the Best Paper Award at the MICCAI conference in Marrakesh. Why it matters: This offers a more efficient and effective way to leverage foundation models in specialized medical imaging applications, potentially improving diagnostic accuracy and reducing the need for large-scale, domain-specific training data.
MBZUAI researchers developed a machine-learning method to predict antimicrobial resistance (AMR) by analyzing electronic health records. The system predicts if a patient will experience AMR when prescribed an antibiotic or if infected with a bacterium. Published in Scientific Reports, the innovation helps physicians identify patients at risk for AMR by using patient demographics, lab results, and physician notes. Why it matters: This approach can help combat the rise of drug-resistant bacteria by providing timely predictions and supporting more informed prescription decisions.
The Abu Dhabi Department of Health (DoH) has partnered with MBZUAI and Core42 to launch the Global AI Healthcare Academy. The academy will provide AI training to healthcare workers in Abu Dhabi, aiming to improve diagnostics, operational efficiency, and patient care. The initiative includes mass training sessions for up to 100 attendees and customized courses in areas like AI for radiology and cardiology. Why it matters: This partnership signals a strategic push to integrate AI into Abu Dhabi's healthcare system, potentially establishing the emirate as a leader in technology-driven healthcare.
MBZUAI researchers collaborated with Carnegie Mellon University and the Broad Institute of MIT and Harvard to develop a new statistical method for analyzing data used for gene regulatory network inference. The method addresses the challenge of distinguishing true zero expression values from dropouts in single-cell RNA sequencing data. This research will be presented at the Twelfth International Conference on Learning Representations (ICLR 2024). Why it matters: Improving gene regulatory network inference can lead to better understanding of disease mechanisms and inform the development of new medicines.