KAUST Discovery Professor Jesper Tegnér collaborated with UK researchers to develop algorithms explaining decision-making in insects and rats. Assoc. Prof. Robert Hoehndorf's lab introduced a tool for identifying genetic variants linked to rare diseases based on patient symptoms. KAUST scientists also studied monkeypox infection of human skin using stem cells and marine microbiome adaptation to thermal changes. Why it matters: These diverse research projects highlight KAUST's contributions to computational biology, virology, and marine science, advancing knowledge with implications for healthcare and environmental challenges.
MBZUAI is developing AI-powered applications to help reduce malaria's impact in Indonesia, supported by Sheikh Mohamed bin Zayed Al Nahyan's Reaching the Last Mile initiative. The applications use sensory data fusion to create "digital twins" for precise weather forecasting and real-time environmental representation. AI and clustering analysis identify recurring features contributing to malaria outbreaks, enabling preventative measures and early treatment. Why it matters: This project demonstrates AI's potential in combating climate-sensitive diseases and improving public health in vulnerable regions.
KAUST and the SFDA co-hosted the "Trends in Microbiome and Digital One Health" conference from October 30 to November 1, 2023, featuring 35 speakers from five continents. Discussions centered on microbiome science, digital tools for tracking microbial epidemiology, and their roles in the One Health concept. The conference facilitated the formation of a consortium for microbiome and Digital One Health research. Why it matters: This event highlights Saudi Arabia's growing focus on leveraging microbiome research and digital technologies to address public health challenges and promote international collaboration in the field.
KAUST researchers used cryogenic electron microscopy (cryo-EM) to study the 3D structure of protein complexes involved in DNA replication and repair. They investigated the interaction between the Y-family TLS polymerase Pol K and mono-ubiquitylated PCNA. The study revealed that DNA binding is required for Pol K to form a rigid, active complex with PCNA. Why it matters: Understanding these structural interactions may provide insights into cancer development and drug resistance mechanisms.
This study investigates the correlation between Google Trends data for COVID-19 symptoms and the actual number of COVID-19 cases in Saudi Arabia between March and October 2020. The researchers found that searches for "cough" and "sore throat" were most frequent, while "loss of smell", "loss of taste", and "diarrhea" showed the highest correlation with confirmed cases. The study concludes that Google searches can serve as a supplementary surveillance tool for monitoring the spread of COVID-19 in Saudi Arabia. Why it matters: The research demonstrates the potential of using readily available digital data to augment traditional surveillance methods for public health monitoring in the region.
KAUST researchers are developing a streamlined COVID-19 diagnostic testing method using superparamagnetic nanoparticles (MNPs). The team, led by Assistant Professor Mo Li, aims to address reagent shortages and improve automation by creating an in-house extraction kit compatible with inactivated samples. Associate Professor Samir Hamdan identified a protocol for making silica-coated MNPs that survive inactivation reagents, enabling magnetic separation without centrifugation. Why it matters: This innovation could significantly increase testing capacity in Saudi Arabia and globally by reducing biosafety risks, reagent dependence, and manual processing.
Malaria No More, the Crown Prince Court of Abu Dhabi, and the Reaching the Last Mile program launched the Institute for Malaria and Climate Solutions (IMACS) to combat malaria amidst climate change. Mohamed Bin Zayed University for Artificial Intelligence (MBZUAI) joined as a technical partner, providing research support leveraging AI and data science. The initiative aims to develop and implement AI-driven strategies to address the impact of climate change on malaria transmission. Why it matters: This partnership highlights the UAE's commitment to using AI for global health challenges, particularly in combating climate-sensitive diseases like malaria.
SaudiVax, located in the KAUST Research & Technology Park, is collaborating with the University of Pittsburgh and Merck France to develop a COVID-19 antibody injection. The antibody both protects against potential infection and neutralizes the virus in those already infected. SaudiVax is utilizing KAUST expertise and has contracted with Merck France for manufacturing since suitable facilities are not yet available in Saudi Arabia. Why it matters: This partnership highlights the growing biopharmaceutical capabilities in Saudi Arabia and the potential for KAUST to serve as a hub for medical innovation in the region.