MBZUAI researchers have developed MorphDiff, a diffusion model that predicts cell morphology from gene expression data. MorphDiff uses the transcriptome to generate realistic post-perturbation images, either from scratch or by transforming a control image. The model combines a Morphology Variational Autoencoder (MVAE) with a Latent Diffusion Model, enabling both gene-to-image generation and image-to-image transformation. Why it matters: This could significantly accelerate drug discovery and biological research by allowing scientists to preview cellular changes before conducting experiments.
This paper introduces SemDiff, a novel method for generating unrestricted adversarial examples (UAEs) by exploring the semantic latent space of diffusion models. SemDiff uses multi-attribute optimization to ensure attack success while preserving the naturalness and imperceptibility of generated UAEs. Experiments on high-resolution datasets demonstrate SemDiff's superior performance compared to state-of-the-art methods in attack success rate and imperceptibility, while also evading defenses.
This paper introduces Diffusion-BBO, a new online black-box optimization (BBO) framework that uses a conditional diffusion model as an inverse surrogate model. The framework employs an Uncertainty-aware Exploration (UaE) acquisition function to propose scores in the objective space for conditional sampling. The approach is shown theoretically to achieve a near-optimal solution and empirically outperforms existing online BBO baselines across 6 scientific discovery tasks.
MBZUAI researchers presented DEFUSE-MS at MICCAI 2025, a novel AI system for analyzing changes in MRI scans of multiple sclerosis (MS) patients. DEFUSE-MS uses a deformation field-guided spatiotemporal graph-based framework to identify new lesions by reasoning about how the brain has changed. The model constructs graphs of small regions within baseline and follow-up MRIs, linking them across time with edges enriched with learned embeddings of the deformation field. Why it matters: DEFUSE-MS reframes the task from simple "spot the difference" to understanding structural changes, potentially improving the speed and accuracy of MS diagnosis and treatment monitoring.
The paper introduces VENOM, a text-driven framework for generating high-quality unrestricted adversarial examples using diffusion models. VENOM unifies image content generation and adversarial synthesis into a single reverse diffusion process, enhancing both attack success rate and image quality. The framework incorporates an adaptive adversarial guidance strategy with momentum to ensure the generated adversarial examples align with the distribution of natural images.
The paper introduces ScoreAdv, a novel approach for generating natural adversarial examples (UAEs) using diffusion models. It incorporates an adversarial guidance mechanism and saliency maps to shift the sampling distribution and inject visual information. Experiments on ImageNet and CelebA datasets demonstrate state-of-the-art attack success rates, image quality, and robustness against defenses.