KAUST researchers led by Dr. Niveen Khashab have developed thermosensitive liposomes for controlled drug release, particularly in cancer therapies. The liposomes are designed to release drugs only when they reach heated tumor tissue, minimizing systemic side effects. Cholesterol moieties are used as anchors to create a "nail" or "comb" effect, enabling temperature-triggered drug release inside cells. Why it matters: This targeted drug delivery system could significantly improve the efficacy and reduce the toxicity of cancer treatments.
KAUST Ph.D. student Khalil Moussi won two awards at the IEEE International Conference on Nano/Micro Engineered and Molecular Systems for his research on a miniaturized drug delivery system. The system, developed in collaboration with KAIMRC, uses 3D printing and wireless power to deliver drugs for coronary artery disease treatment. The device features an electrochemical micro-pump, a 3D printed reservoir with microneedles, and a wireless powering unit, allowing customization for various in vivo drug delivery applications. Why it matters: This recognition highlights KAUST's contributions to biomedical engineering and its potential to develop innovative solutions for critical healthcare challenges in the region and beyond.
Scientists at King Abdullah University of Science and Technology (KAUST) have engineered tiny metal-organic frameworks (MOFs) to deliver a team of six proteins into living cells. Inside the cells, these proteins formed a nanoscale factory that successfully produced violacein, a natural bioactive compound with therapeutic potential. This breakthrough represents the most complex multiprotein system delivered into living cells to date and the first example of a 'protein pathway transplant'. Why it matters: This research offers an early demonstration of how future therapies might generate treatment molecules directly inside the body at disease sites, potentially leading to more precise and less toxic medical interventions.