New study explores how cells respond to acidic stress

Summary

Researchers at King Abdullah University of Science and Technology (KAUST) found that restoring a key cellular molecule, NAD+, can partially reverse the effects of acidic stress in human cells. Published in Communications Biology, their study utilized a precisely controlled bioreactor system to investigate how mild extracellular acidity disrupts cellular energy generation and mitochondrial function. The research identified NAD+ depletion as a key underlying mechanism and demonstrated that NMN supplementation partially restored cellular function and reduced mitochondrial dysfunction. Why it matters: These findings could inform future strategies to protect cells and support human health, particularly in diseases like cancer and inflammation where acidic conditions are common.